Abstract
A series of coumarin derivatives with attached heterocyclic pyrazoline rings have been synthesized from ethyl acetoacetate and salicylaldehyde. All the final products were characterized and screened for their in vitro activities as antioxidants and anti-inflammatory agents. The antioxidant activity was studied by DPPH free radical scavenging method and the IC50 values were calculated for comparison with a standard (ascorbic acid) at the same dose. Several compounds (C1, C4, C7, C8, C9 and C10) have shown promising results. RBC membrane stabilization model was used to evaluate the in vitro anti-inflammatory activity, and compounds C1, C3, C7 and C9 showed effective inhibition of hemolysis in comparison compared to acetylsalicylic acid as the standard. Upon studying the structure – activity relationship (SAR), it has been concluded that electron withdrawing substitutions at para position are most potent as antioxidants as well as anti-inflammatory agents.
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