Abstract
In this paper we present the synthesis of a novel series of 3-(5-methyl-1-aryl-1 H -1,2,3-triazol-4-yl)-1-phenyl-1 H -pyrazoles 3-6 by employing Vilsmeier-Haack reaction followed by Knoevenagel condensation on 1-aryl-3-acetyl-4-methyl-1,2,3-triazoles 1a,b. The cytotoxicity and in vitro anticancer evaluation of the prepared compounds have been assessed against four different human cancer cell lines including breast MCF-7; liver HepG2 and lung cancer A549 as well as human normal melanocyte HFB4. The results revealed that the prepared compounds exert their actions in MCF-7 and HepG2. Compounds 4a and 6a revealed promising anticancer activity compared to the activity of the commonly used anticancer drug, doxorubicin. MCF-7 cells are slightly more sensitive to the tested compounds than HepG2 cells.
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