Synthesis and in Vitro Biological Activity Study of Novel Phenol Mannich Base Analogs Containing Spiroheterocycle as Core Compound

Abstract

The condensation reactions between Gabapentin lactam and phenols have been carried out in the presence of formaldehyde for the synthesis of various mannich base series. To confirm the formation of these series of newly prepared mannich bases thus synthesized, various characterization techniques have been used, such as, GC-MS, 1H-NMR, 13C-NMR and FT-IR. Further their antibacterial and antifungal activities against pathogenic bacteria have been evaluated. These compounds show promising activities against the pathogenic bacteria, hence are useful as antibacterial and antifungal active compounds.