Synthesis and In-vitro Antibacterial Activity of New <I>N</I>-Substituted Piperazinyl Quinolones

Abstract

A series of N-[2-(2-furyl)-2-oxoethyl], N-[2-hydroxyimino-2-(2-furyl)ethyl], N-[2-(2-furyl)-2-methoxyiminoethyl] and N-[2-(2-furyl)-2-phenylmethoxyiminoethyl] piperazinyl quinolones were synthesized and evaluated for in-vitro antibacterial activity. Compounds with a 2-(2-furyl)-2-oxoethyl group attached to the piperazine ring had similar antibacterial activity to the reference drugs, norfloxacin and ciprofloxacin, against staphylococci, but significantly decreased activity against Gram-negative bacteria. If the hydrogen of oxime was replaced with a methyl or benzyl group, in-vitro antibacterial activity decreased against Gram-negative bacteria, but activity was similar against staphylococci. Generally, ciprofloxacin derivatives were more active than norloxacin derivatives.