Synthesis and in vitro antibacterial activity of cephalosporins with a pyridinium substituent carrying an isoxazole moiety at the C-3 position.

Abstract

Several quaternary pyridinium cephalosporin analogues were prepared and evaluated in vitro for antibacterial activity against selected gram-positive and gram-negative organisms. Most of the synthesized analogues were either as effective or less effective against the tested bacterial organisms than the reference compounds, Cefpirome and Ceftazidime.