Synthesis and in vitro activity investigation of some dibutyl-, diphenyl- and triphenyltin(IV) carboxylates against leukemia cancer cell, L-1210

Abstract

Abstract Successful synthesis of several dibutyl-, diphenyl- and triphenyltin(IV) carboxylate compounds and evaluation of their activity as anticancer against leukemia cancer cell, L-1210 was reported. The compounds were synthesized by reacting dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (4) and triphenyltin(IV) hydroxide (TPTOH) (7) with respective carboxylic acids, and subsequently characterized using NMR, FTIR, and UV–Vis spectroscopies, microelemental analyzer, and melting point apparatus. The compounds were then tested as anticancer, revealing that derivatives of triphenyltin(IV) (compounds 8 dan 9) exhibit the IC50 value of 3.7 and 2.9 μg/mL, respectively, which are much higher activity than those of dibutyltin(IV) and diphenyltin(IV) derivatives.