Abstract
Novel bioactive glasses based on a Ca- and Mg-modified silicon oxycarbide (SiCaMgOC) were prepared from a polymeric single-source precursor, and their in vitro activity towards hydroxyapatite mineralization was investigated upon incubating the samples in simulated body fluid (SBF) at 37 °C. The as-prepared materials exhibit an outstanding resistance against devitrification processes and maintain their amorphous nature even after exposure to 1300 °C. The X-ray diffraction (XRD) analysis of the SiCaMgOC samples after the SBF test showed characteristic reflections of apatite after only three days, indicating a promising bioactivity. The release kinetics of the Ca2+ and Mg2+ and the adsorption of H+ after immersion of SiCaMgOC in simulated body fluid for different soaking times were analyzed via optical emission spectroscopy. The results show that the mechanism of formation of apatite on the surface of the SiCaMgOC powders is similar to that observed for standard (silicate) bioactive glasses. A preliminary cytotoxicity investigation of the SiOC-based bioactive glasses was performed in the presence of mouse embryonic fibroblasts (MEF) as well as human embryonic kidney cells (HEK-293). Due to their excellent high-temperature crystallization resistance in addition to bioactivity, the Ca- and Mg-modified SiOC glasses presented here might have high potential in applications related to bone repair and regeneration.
Highlights
Bioactive glasses (BGs) and bioactive glass–ceramics (BGCs) of specific compositions have been studied for the last four decades as suitable materials for bone regeneration purposes since Hench et al found that the melt-quenched CaO–SiO2 –P2 O5 –Na2 O system (e.g., Bioglass® 45S5) was able to tightly bond to the bone [1]
Novel glass compositions based on SiOC and SiOC modified with Ca and Mg intended for bone regeneration applications were prepared, and their in vitro activity was investigated after incubating the samples in simulated body fluid (SBF) at 37 ◦ C
The formation of hydroxyl-carbonated apatite (HCA) on the surface of the glass after incubation was assessed by X-ray diffraction (XRD), while the biodegradation of its components was studied mainly via optical emission spectroscopy
Summary
Bioactive glasses (BGs) and bioactive glass–ceramics (BGCs) of specific compositions have been studied for the last four decades as suitable materials for bone regeneration purposes since Hench et al found that the melt-quenched CaO–SiO2 –P2 O5 –Na2 O system (e.g., Bioglass® 45S5) was able to tightly bond to the bone [1]. BGs containing SiO2 as network former and glass–ceramic compositions are able to stimulate tissue. Materials 2016, 9, 959 regeneration by inducing the formation of surface active layers much faster than other bioactive ceramics that do not contain Si in their composition; for example, silica-based bioactive glasses induce the formation of a surface-active layer three times faster than does hydroxyapatite [3,4,5,6]. The glass devitrifies during sintering to form a predominantly crystalline phase (Na2 O−2CaO−3SiO2 )
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
