Synthesis and In-silico Study of Novel 1,3,4-Oxadiazole Derivatives : A Biologically active Scaffolds which induce Anti-tubercular activity by targeting Pteridine Reductase and Dihydrofolate Reductase

Abstract

Heterocyclic compounds possess diverse biological properties that have led to intense study and research of these compounds. One of these compounds is Oxadiazole which has been found to exhibit various pharmacological activities. 1,3,4-oxadiazole having heterocyclic nucleus is a novel molecule which attract the chemist to search a new therapeutic molecule. Research on 1,3,4-oxadiazole and their synthetic analogues have revealed a variety of pharmacological activities including anti-microbial, anti-tubercular and insecticidal agents. Some of these compounds have also analgesic, anti-inflammatory, anti-cancer, anti-HIV agent, anti-parkinsonian and anti-proliferative agent. It was our interested to make novel derivatives of the titled compounds and evaluate the anti-tubercular activities. 1,3,4-oxadiazole and its derivatives (4a-4e) were obtained. The current study discusses the microwave irradiation synthesis of derivatives with the goal of generating new medications with high specificity for mycobacterium tuberculosis and low harm to the human.