Synthesis and Identification and Biological Studies of New Azo Dyes Derived from Imidazole and their Chelate Complexes

Abstract

Anew azo ligand (E)-2-((4- fluoro phenyl)diazenyl)-4,5-bis(4-methoxy phenyl)-1H-imidazolehas beensynthesized from coupling 4,5-bis(4-methoxyphenyl)imidazole with para-chloro-anline. The structures ofthe new ligand and their transition metal complexes ware investigated and characterized using differentphysicochemical studies as elemental analysis, IR spectra, 1HNMR,, UV-Vis spectra, mass spectra, Molarconductance ,and magnetic susceptibility .The complexes were found to have the general formula [ML2Cl2].H2O where M = Co(II), Ni(II), Cu(II) ,Mn(II),and Fe(II), [MLCl2].H2Owhere M=Zn(II),Cd(II),Hg(II), andPd(II). The IR results demonstrate that the co-ordination sites are the azomethine nitrogen of the imidazolering and azo nitrogen atom of the azo ligand. The electronic spectral and magnetic measurement dataindicate that the complexes exhibit octahedral geometry,except the Zn(II),Cd(II),andHg(II) complexessuggest tetrahedral and Pd(II) a square planar geometry.The cytotoxicity of Pd(II) complex on human LungCancer (SCLC) and normal cells.