Synthesis and herbicidal activity of novel 1,2,4-triazole derivatives containing fluorine, phenyl sulfonyl and pyrimidine moieties

Abstract

In this study, 4-amino-2-(alkylthio)-6-(methylthio) pyrimidine-5-carbonitrile Ι were employed as the starting materials to synthesize a novel series of 1,2,4-triazole derivatives containing fluorine, phenyl sulfonyl and pyrimidine moieties Ⅳ-1∼Ⅳ-39. The preliminary bioassay indicated that many newly synthesized compounds exhibited moderate to good herbicidal activities against the monocotyledons (Echinochloa crusgalli, Sorghum bicolor) and dicotyledons (Raphanus sativus, Brassica campestris, Cucumis sativus, and Medicago sativa) at the concentrations of 100 mg·L−1 and 10 mg·L−1. Especially, compound (Ⅳ-8) displayed good herbicidal activity, with 100% inhibition against Brassica campestris, Cucumis sativus, and Medicago sativa at a concentration of 100 mg·L−1.