Abstract
Two new fluorinated imidazo[1,2- a]pyridine derivatives, 6-(2′-fluoroethyl)-2-(4′-dimethylamino)phenylimidazo[1,2- a]pyridine (FEPIP) and 6-(3′-fluoropropyl)-2-(4′-dimethylamino)phenylimidazo[1,2- a]pyridine (FPPIP), were synthesized. The binding affinity for FEPIP and FPPIP to amyloid plaques in human AD cortical tissues was determined. Radiolabeling, in vitro film autoradiography, and micro-PET study were performed with [ 18F]FPPIP to determine its utility as a radioligand for amyloid plaque imaging in the brain of AD patients.
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