Abstract
Objective: To synthesize and evaluate taste-masked ionic liquid (IL) salts of loratadine.
 Methods: In the present work, pharmaceutically active IL salts of loratadine using selected counter-ions were synthesized. The synthesized IL salts were characterized using melting point, Ultraviolet (UV) spectroscopy, Fourier Transform Infra-Red (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD). These salts were also evaluated for solubility, dissolution, and palatability studies.
 Results: All synthesized IL salts of loratadine exhibited melting points below 100 °C. UV spectral data and FTIR data confirmed the formation of new salt forms with selected counter-ions. The absence of sharp melting point peaks during DSC studies revealed the amorphous nature of new salt forms. During XRD studies, loratadine-indomethacin IL salt yields completely amorphous compound while the intensity of characteristic peaks of loratadine was found to be reduced with other counter-ions. Solubility studies revealed that the solubility of loratadine is reduced from 35.85 mg/ml to 3.63 mg/ml, 15.39 mg/ml, 5.31 mg/ml, and 3.71 mg/ml in case of IL-1, IL-2, IL-3, and IL-4, respectively. Dissolution studies further confirmed this finding. Except for oleate, all the IL salts were found to be palatable by subjects with the score ranging from 2.5 to 2.8, which is the standard range for palatability.
 Conclusion: Results obtained in the present work indicated that IL salts of loratadine can be synthesized successfully using selected counter-ions. This approach can be used to mask the bitter taste of pure loratadine and thus can be used for the development of drug products intended for children.
Highlights
Ionic liquid (IL) salts are a new class of purely ionic, salts of compounds that have very low melting points
The melting point of loratadine and synthesized IL salts are presented in table 2
The melting point of each synthesized IL salt showed a significant reduction in melting point
Summary
Ionic liquid (IL) salts are a new class of purely ionic, salts of compounds that have very low melting points Many times they exist in the liquid state at room temperature. The intensity of charge in a localized area reduces and crystal packing becomes loose This is the reason for the low melting points of IL salts. On the other hand, have symmetrical packing in their crystal structure and charges are well localized [4]. These IL salts have additional properties like nonflammable [1], thermally, mechanically, and electrochemically stable [5, 6], etc. Due to such unique properties of IL salts, these are used as solvents in synthesis and separation of organic compounds [1, 7,8,9], as thermal fluids [10], lubricants [10], electrolytes [10], electroelastic materials [11], etc
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