Abstract
Some 3-(3-(7-chloroquinolin-4-ylamino)propyl-2-imino-5-(4-chloro/nitro/methoxy benzylidene) oxazolidin-4-one 4(a–c) and 4-(3-(7-chloroquinolin-4-ylamino) propyl)-2(4-chloro/nitro/methoxy benzylidene)-1,6-diox-4,9 diazaspiro[4,4]nonane-3,8-dione 5(a–c) derivatives were synthesized using appropriate synthetic route. The newly prepared compounds 5a–c demonstrated inhibitory effects on the growth of a MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line on leukemia). The MCF7 cell line was found to be very susceptible towards compound 5a with IC50 values of 16 μg/ml. Similarly, the HT29 cell line was found to be moderately susceptible towards compounds 5a and 5c with IC 50 values of 32 and 49 μg/ml, respectively. A series of novel spiro oxazolidinone 5(a-c) was synthesized in multistep reactions. Newly synthesized compounds were characterized and screened for their in-vitro cytotoxic potential against MCF7 and HT29 cell lines.
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