Abstract
3,6-Disubstituted pyridazine analogs (2a and 2b) were synthesized from commercially available 3,6- dichloropyridazine in two steps. The synthesized compounds were evaluated for their GPR119 agonistic activity. Both compounds exhibited much stronger EC50 values than that of oleylethanolamide (OEA) and were proved to be partial agonists. These results indicate that the pyridazine ring can be used as a potential heterocycle scaffold for GPR119 agonists.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
