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https://doi.org/10.1016/j.bmc.2011.12.040
Copy DOIJournal: Bioorganic & Medicinal Chemistry | Publication Date: Dec 27, 2011 |
Citations: 21 |
Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups.
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