Abstract

Synthesis and evaluation of ?-hydroxy fatty acid-derived heterocyclic compounds with potential industrial interest

Highlights

  • The reaction of 2-hydroxyheptadecanoyl chloride (2) and anthranilic acid gave 2-(1-hydroxyheptadecyl)-4H-3,1benzoxazin-4-one (3) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by a reaction with nitrogen nucleophiles

  • They have good storage stability in detergents (Mohamed et al, 2003). This led us to synthesize 2-(1hydroxyheptadecyl)-4H-3,1-benzoxazin-4-one (3) and several quinazoline derivatives which may have pharmaceutical and industrial applications. This encouraged us to synthesize a novel group of nonionic surface active agents containing these nuclei

  • These compounds have a double function as antimicrobial and as surface active agents which may serve in the manufacturing of drugs, cosmetics, pesticides or as antibacterial and/or antifungal agents

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Summary

SUMMARY

Synthesis and evaluation of α-hydroxy fatty acidderived heterocyclic compounds with potential industrial interest. This led us to synthesize 2-(1hydroxyheptadecyl)-4H-3,1-benzoxazin-4-one (3) and several quinazoline derivatives which may have pharmaceutical and industrial applications This encouraged us to synthesize a novel group of nonionic surface active agents containing these nuclei. These compounds have a double function as antimicrobial and as surface active agents which may serve in the manufacturing of drugs, cosmetics, pesticides or as antibacterial and/or antifungal agents. The surface properties such as surface and interfacial tension, cloud point, foaming height, wetting time, and emulsification power were determined.

MATERIALS AND METHODS
INTRODUCTION
2.15.2. Cloud point
2.15.3. Wetting time
2.15.4. Foaming properties
2.15.5. Emulsification stability
2.16. Biodegradability
2.17. Biological activity
Synthesis
Surface and interfacial tensions
Cloud point
Foam power
Emulsion stability
Biodegradability
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