Abstract
AbstractThe four hederagenin glycosides 1–4 were efficiently synthesized through one‐pot sequential glycosylations with glycose 1‐(trichloroacetimidate)s as donors, resulting in a significantly simplified synthetic procedure without isolation of glycosylation intermediates. The activity of the synthetic hederagenin glycosides 1–4 against α‐glucosidase type IV was evaluated; hederagenin glycoside 4 containing an α‐L‐rhamnopyranosyl unit showed the best activity with an IC50 value of 47.9 μM.
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