Abstract
The novel quaternary ammonium bromide (QAB)-containing oligomers were synthesized and applied for developing an antibacterial resin composite. Compressive strength (CS) and S. mutans (an oral bacteria strain) viability were used to evaluate the mechanical strength and antibacterial activity of the formed composites. All the QAB-modified resin composites showed significant antibacterial activity and mechanical strength reduction. Increasing chain length and loading significantly enhanced the antibacterial activity but dramatically reduced the CS as well. The 30-day aging study showed that the incorporation of the QAB accelerated the degradation of the composite, suggesting that the QAB may not be well suitable for development of antibacterial dental resin composites or at least the QAB loading should be well controlled, unlike its use in dental glass-ionomer cements. The work in this study is beneficial and valuable to those who are interested in studying antibacterial dental resin composites.
Highlights
Long-lasting restoratives and restoration are clinically attractive because they can reduce patents’ pain and expense as well as the number of their visits to dental offices [1,2,3,4]
The 30-day aging study showed that the incorporation of the quaternary ammonium bromide (QAB) accelerated the degradation of the composite, suggesting that the QAB may not be well suitable for development of antibacterial dental resin composites or at least the QAB loading should be well controlled, unlike its use in dental glass-ionomer cements
The work in this study is beneficial and valuable to those who are interested in studying antibacterial dental resin composites
Summary
Long-lasting restoratives and restoration are clinically attractive because they can reduce patents’ pain and expense as well as the number of their visits to dental offices [1,2,3,4]. In dentistry, both restorative materials and oral bacteria are believed to be responsible for the restoration failure [2]. Secondary caries is found to be the main reason to the restoration failure of dental restoratives including resin composites and glass-ionomer cements [1,2,3,4]. Release or slow-release can lead or has led to a reduction of mechanical properties of the restoratives over time, short-term effectiveness, and possible toxicity to surrounding tissues if the dose or release is not properly controlled [5,6,7,8,9]
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