Abstract
In this study, ethylene diamine tetraacetic acid-deoxyglucose (EDTADG) ligand was successfully synthesized and then radiolabeled with 99mTc directly to produce 99mTc-EDTADG with high radiochemical purity. 99mTc-EDTADG showed good in vitro stability. The partition coefficient and electrophoresis results showed it was hydrophilic and negatively charged. The biodistribution study in mice bearing S180 tumor showed that 99mTc-EDTADG had high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Single photon emission computed tomography imaging clearly visualized the tumor, suggesting it could be considered as a potential agent for tumor imaging.
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