Synthesis and Evaluation of 2, 4, 5 - Trisubstituted and 1, 2, 4, 5 Tetrasubstituted Imidazole as Antimicrobial Agents

Abstract

A series of 2,4,5-trisubstituted (A1-A15) and 1,2,4,5-tetrasubstituted (B1-B7) imidazole derivatives were synthesized by the reaction of Benzil, aldehyde, ammonium acetate, aromatic primary amines using catalyst tetrabutylammoniumbromide in isopropanol. Structures of these compounds were elucidated by spectral (IR, 1 H NMR) analysis. The newly synthesized compounds were screened for antifungal and antibacterial activities. The activity was measured in terms of zone of inhibition and compared with standard drug. Compounds A4,A7,A8,A10,A12,A14,A15,B1,B3,B5 and B6 have shown good antibacterial activity against std. Norfloxacin and Compound A2,A3,A6,A7,A9,A10,A14,A15,B2,B3,B4,B6 and B7 exhibited good antifungal activities against std. Clotrimazole, and other compound shows moderate activity.