Abstract
Our interest to design a novel class of antisense oligonucleotides has lead us to prepare acyclic thymidine dimer analogues having an unique constrained antiglycosidic conformation. These dimer analogues showed remarkable resistance to nuclease degradation, such as Nuclease S1, Bovine Spleen Phosphodiesterase, and Snake Venom Phosphodiesterase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
