Synthesis and electro-catalytic evaluation of Ti(IV)-anchored heterogeneous mesoporous material for uric acid analysis

Abstract

A simple and modified synthetic strategy has been developed for the preparation of Ti(IV) anchored mesoporous MCM-41 material from the commercially available starting material of titanocene dichloride and MCM-41. The vacuum diffusion process has been utilized for anchoring Ti(IV) on MCM-41 (Ti-MCM-41) via surface activation instead of the chemical activation process. The modified Ti-MCM-41/glassy carbon electrode (GCE) was developed from Ti-MCM-41 and evaluated for the selective sensing of mammalian metabolic bio-marker of uric acid (UA) by the electrochemical method. The modified electrode (Ti-MCM-41/GCE) shows an excellent selective electrochemical response with UA, good linear competence in wide range concentrations (10–110 nM) and scan rates (50–900 mV s−1) and a low limit of detection up to 2.98 nM in the category of silica based mesoporous material. The selectivity and sensitivity of the electrode were tested with various potential organic interferents that exhibit good anti-interferents activity. The proposed modified electrode is potentially useful for commercial sensing application of UA since the analysis of human urine samples under various age people are good agreements with recovered UA by the standard addition method. The stability and reproducibility of the Ti-MCM-41/GCE were tested and the results are reproducible in a number of electro-catalytic cycles.