Abstract
Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor
Highlights
A Platinum Open Access Journal for Organic ChemistrySynthesis and density functional theory (DFT) studies of novel aminoimidazodipyridines using 2-(3Himidazo[4,5-b]pyrid-2-yl)acetonitrile as an efficient key precursor
Imidazo[4,5-b]pyridines are important classes of heterocyclic compounds that possess diverse pharmacological properties including anticancer,[1] antimicrobial,[2] anti-inflammatory,[3] and antiviral activities.[4,5] N-fused polyheterocycles display a wide range of biological activities.[6]
In connection with the increasing interest of adoption of new synthetic methods in drug discovery, and in continuation to our recent applications of carbon-Michael[15,16,17,18] as well as aza-Michael[16] addition reactions as powerful tools for the synthesis of nitrogen containing heterocycles and their corresponding bisheterocycles,[15,17,19,20,21,22,23,24,25,26] we report our investigation on the reactivity of 2-(3H-imidazo[4,5-b]pyrid-2yl)acetonitrile towards arylidenemalononitriles and bis-arylidenemalononitriles aiming at synthesizing novel mono- and bis-imidazo[1,2-a:5,4-b']dipyridine-6,8-dicarbonitriles
Summary
Synthesis and DFT studies of novel aminoimidazodipyridines using 2-(3Himidazo[4,5-b]pyrid-2-yl)acetonitrile as an efficient key precursor. Salema aDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt bDepartment of Chemistry, Faculty of Science, Helwan University, Cairo 11795, Egypt
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