Synthesis and drug-loading properties of folic acid-modified superparamagnetic Fe3O4 hollow microsphere core/mesoporous SiO2 shell composite particles

Abstract

A drug delivery system, which not only has superparamagnetic property, higher surface area but also has targeting function, has been developed. The core/shell structural magnetic magnetite mesoporous silica microspheres with amine groups (Fe3O4–SiO2–NH2) were first fabricated by a one-pot direct co-condensation method, then folic acid-modified magnetic mesoporous silica composite microspheres (Fe3O4–SiO2–NHFA) were obtained by the bonding of the Fe3O4–SiO2–NH2 with folic acid as targeted molecule. The resultant composite microspheres were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, low temperature nitrogen adsorption–desorption, and vibrating sample magnetometer. A well-known inflammational drug ibuprofen was used as a model drug to assess the loading and releasing behavior of the composite microspheres. Fe3O4–SiO2–NHFA system exhibits magnetic properties typical for superparamagnetic material with a higher saturation magnetization value of about 41.2 emu/g and has better capacity of drug storage (32.0 %) and sustained drug-release property. So this system has potential applications in biomedical field.