Abstract
In this study, Fe3O4@silica nanotubes (Fe3O4@SiNTs) were synthesized through a co-axial electrospinning of a shell-liquid consisting of tetraethoxysilane, polyvinyl pyrrolidone, ethanol and hydrogen chloride and Fe3O4 nanoparticles (NPs) and a core-liquid of paraffin. Their microstructure and drug delivery property were evaluated. SEM observations showed that Fe3O4@SiNTs had the tubular hollow structure. The presence of magnetic component caused a magnetic separability of Fe3O4@SiNTs. After soaked in the solution of tetracycline hydrochloride (TH, one of the representative antibiotics), Fe3O4@SiNTs supported the adsorption of TH with the loading efficiency of 64±5% to produce TH-loaded Fe3O4@SiNTs. TH-loaded Fe3O4@SiNTs presented a sustained release behavior for TH after soaked in the phosphate buffer saline. After incubation with Escherichia coli (E. coli, one of the most widely used bacteria), TH-loaded Fe3O4@SiNTs exhibited strong anti-bacterial property to inhibit the growth of E. coli, indicating that the released TH was biologically active.
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