Abstract
The bridged tricyclic dopamine analogues exo-2-( N-n-propylamino)-6,7-dihydroxybenzonorbornene, exo-2-( N,N-di- n-propylamino)-6,7-dihydroxybenzonorbornene, and exo-2-amino-6,7-dihydroxybenzobicyclo[2.2.2]octene have been synthesized and assayed for their effects on the binding of [ 3H]spiperone and [ 3H]apomorphine to rat striatal membranes. The inactivity of these compounds is rationalized on the basis of proposed topographical models of dopamine receptors.
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