Abstract
Mono-modified β-cyclodextrins ligands, L1 (6-mono-(N-aminoethyl) amino-β-cyclodextrin) and L2 (6-mono-(N-(pyridin-2-yl) ethylamino)-β-cyclodextrin), and their platinum (II) complexes, 1 ([Pt (L1)Cl2]·8H2O) and 2 ([Pt (L2)Cl2]·4H2O), were successfully synthesized. As revealed by UV-Vis and CD spectroscopic studies, both complexes mainly adopt a non-intercalative mode with DNA. The interaction between platinum complex 1 and DNA was obviously observed in agarose Gel Electrophoresis. Meanwhile, two ligands L1, L2 and platinum complex 2 have no obvious interaction with DNA. The difference interaction between complexes 1, 2 and DNA should be ascribed to their different structures.
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