Abstract

SummaryA method was described for synthesis of 1-benzyl-2-methyl-5-hydroxytryptamine involving cleavage of the methyl ether of 1-benzyl − 2-methyl − 5-methoxytryptamine (BAS) by heating with pyridine hydrochloride. The phenol so produced exhibited powerful antiserotonin action either orally or intravenously in dogs. In the intravenous test it was the most potent antiserotonin thus far encountered. It also had considerable serotoninlike activity.

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