Abstract
Several novel molecules, 1-(3′-(9 H-carbazol-4-yloxy)-2′-hydroxypropyl)-3-aryl-1 H-pyrazole-5-carboxylic acid derivatives 3a–g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a–g has been prepared by the reaction of ethyl 3-aryl-1 H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9 H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK–N–SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK–N–SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK–N–SH cell growth.
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