Abstract
Phenylurea groups were introduced into the frame of traditional cyanoacrylate and a series of N -(3-benzylamino-2-cyano-3-methylthioacrylyl)- N' -(substituted phenyl)ureas were synthesized. All compounds are new and their structures were confirmed by 1 H NMR, 13 C NMR and mass spectral analyses. KEY WORDS : Synthesis, Cyanoacrylate, Phenylurea derivatives Bull. Chem. Soc. Ethiop. 2013 , 27(2), 295-300. DOI: http://dx.doi.org/10.4314/bcse.v27i2.15
Highlights
The herbicidal activities of cyanoacrylates have been the subject of intense interest in past decades [1,2,3,4]
Cyanoacrylates and phenylurea derivatives both are inhibitors of photosystem II (PSII) electron transport, which inhibit the growth of weeds by disrupting photosynthetic electron transport at a common binding domain on the 32 kD polypeptide of the PSII reaction center [6]
According to the connecting principle of biological activity groups, phenylurea groups are introduced to the frame of cyanoacrylate and novel compounds may exhibit good herbicidal activities
Summary
The herbicidal activities of cyanoacrylates have been the subject of intense interest in past decades [1,2,3,4]. We report the synthesis and structure analysis of N-(3benzylamino-2-cyano-3-methylthioacrylyl)- N'-(substituted phenyl)ureas. A solution of isocyanate 1 in acetone was added dropwise to a solution of ammonia in the same solvent at 0-5 oC afforded substituted phenylurea (2) [7,8].
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