Synthesis and Crystal Structure of Diaqua(1,10-Phenanthroline-N,N′)(Thiosulfato-O,S)Manganese(II). Biological Properties.

Maria Brezeanu,Dung Nguyen Huy,Mikaela Badea,Sylvie Bouttier,Georges Morgant,Dana Marinescu,Bernard Viossat,Jacky Fourniat

doi:10.1155/mbd.1998.305

Abstract

The synthesis of diaqua(1,10-phenanthroline-N,N′)(thiosulfato-O,S)manganese(ll) [Mn(phen)(S2O3)(H2O)2] was investigated. Its structure was determined by single crystal X-ray diffraction from 2418 reflections (I > 3 σ(I)) to a final value of R = 0.047 and Rw = 0.054. Crystal data are as follows : space group P21; a = 10.356(3), b = 7.097(3), c = 20.316(2) Å, β = 94.29(2)°, V = 1489.1(8) , Å3, Z = 2. There are two independent title compounds in the asymetric unit. Each manganese atom has a distorted octahedral Mn(SO)N2O2 geometry with the S and O atoms (from two neighbouring thiosulfate ligands) mutually trans, two N atoms from the 1,10-phenanthroline ligand and two water oxygen. The thiosulfate group behaves as a bridging ligand, connecting, through sulfur and oxygen, Mn atoms related by the binary b translation, thus forming infinite chains running parallel to this axis. Infrared and electronic spectra are reported.

Highlights

The molecule 1,10-phenanthroline and its derivatives are well known to exhibit antifungal, antiviral and mycoplasmal activities [1]
Antiviral activity was found for divalent transition metals with substituted phenanthrolines in the following order of activity Cd > Cu >> Zn >> Mn > Fe > Co > Ni > Ru [2]
These complexes are used as DNA intercalating agents [3] and have been found useful for examining distinctive conformations along the DNA helix [4]

Summary

Introduction

The molecule 1,10-phenanthroline (phen) and its derivatives are well known to exhibit antifungal, antiviral and mycoplasmal activities [1]. Their cytotoxicity might be due to chelation of transition metals such as copper or iron in test media. Antiviral activity was found for divalent transition metals with substituted phenanthrolines in the following order of activity Cd > Cu >> Zn >> Mn > Fe > Co > Ni > Ru [2] These complexes are used as DNA intercalating agents [3] and have been found useful for examining distinctive conformations along the DNA helix [4]. An X-ray study of these complexes would give the coordination around the metal atom but should define the situation of the thiosulfate group, which could in theory coordinate as a monodentate ligand, a bidentate ligand, or as a bridging ligand between different metal atoms

Results and discussion

Materials

Spectroscopic techniques