Abstract
Abstract Diketopiperazines bearing a benzyl moiety with different para-substituents were synthesized and analyzed by 1H NMR spectroscopy. All of these diketopiperazines were found to adopt a folded conformation according to the upfield chemical shift of the cis-proton (cis to the benzyl moiety) due to a shielding effect in the 1H NMR spectra. An intramolecular CH–π interaction appears to be an important factor for the folded conformation due to the effects of para-substituents on the benzyl group.
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