Abstract
Nanosized manganese ferrite (MnFe2O4) particles were prepared by sol–gel method using natural polymers like wheat flour (WF) and potato flour (PF) as surfactants and its structural, morphological, optical and magnetic characteristics were studied by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), scanning electron microscope (SEM), photoluminescence spectroscopy (PL) and vibration sample magnetometer (VSM). Brunauer–Emmett–Teller (BET) surface area test also performed and the results obtained were discussed. The average crystallite size was found to be 23 and 16 nm for WF/MnFe2O4 and PF/MnFe2O4 samples, respectively. Magnetic hysteresis loops confirmed the super-paramagnetic behavior for both the samples. For oxidation of benzyl alcohol to benzaldehyde, the catalytic activity of MnFe2O4 nanoparticles (NPs) was carried out. Antimicrobial and antifungal activity of WF/MnFe2O4 and PF/MnFe2O4 samples were investigated against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae), two Gram-negative bacteria (Pseudomonas aeruginosa, Salmonella paratyphi) and fungus (Candida albicans) using inhibition zone method. Minimum Inhibitory Concentration (MIC) values also calculated to determine susceptibilities of bacteria to drugs and also to evaluate the activity of new antimicrobial agents. The in vitro cytotoxicity of newly synthesized samples were analyzed by MTT assay against MCF-7, A549 and HaCaT cell lines in a dose-dependent fashion. Among these two samples, sample B (using potato flour) shows better response than sample A (using wheat flour) and both the samples were non-toxic to normal cell line. The concentration required to kill 50% of the cell (IC50) was also calculated.Graphical MnFe2O4 nanoparticles were synthesized by sol–gel method using natural polymers, wheat flour and potato flour, as surfactant. The as-prepared MnFe2O4 was characterized by XRD, FT-IR, SEM, EDX, PL and VSM analysis. The average crystallite size was found to be 23 and 16 nm for WF/MnFe2O4 and PF/MnFe2O4 samples, respectively. Magnetic hysteresis loops confirmed the super-paramagnetic behavior for both the samples. The catalytic activity of MnFe2O4 nanoparticles (NPs) were carried out for oxidation of benzyl alcohol to benzaldehyde. Biological activities like antimicrobial, antifungal and anticancer activities of the samples were investigated. Among these two samples, PF/MnFe2O4 shows better response than WF/MnFe2O4 and both the samples were non-toxic to normal cell line. IC50 values of WF/MnFe2O4 (a) and PF/MnFe2O4 (b) against A549 and MCF-7 cell lines
Highlights
Nanomaterials play a vital role in the field of nanomedicine and nanobiotechnology
Spinel structure ferrite nanoparticles creates a great impact among the science researchers because of its wide applications in magnetic resonance imaging, magnetic storage devices, biotechnology, electronics, magnetic drug delivery [8,9,10], etc
Literature survey reveals that manganese ferrite nanoparticles are synthesized by several methods like traditional ceramic methods, oxalate method, sol–gel, chemical co-precipitation, mechanical ball milling, thermal decomposition, hydrothermal, combustion, and micro emulsion method [16,17,18,19]
Summary
Nanomaterials play a vital role in the field of nanomedicine and nanobiotechnology. They can offer a new approach to antibiotic-resistance microbes [1]. In several studies nanoparticles (NPs) can be used as therapeutic tools to treat infections against microbes because of their unique physical, chemical, mechanical and magnetic properties. Magnetic nanoparticles possess excellent super-paramagnetic property due to large surface-to-volume ratio of the nanoparticles and they require super-paramagnetic character at room temperature for many applications [11,12,13,14]. Among all the spinel ferrites known today, MnFe2O4 nanoparticles have high surface area, high saturation magnetization, high mechanical hardness and possess excellent chemical stability [15]. Literature survey reveals that manganese ferrite nanoparticles are synthesized by several methods like traditional ceramic methods, oxalate method, sol–gel, chemical co-precipitation, mechanical ball milling, thermal decomposition, hydrothermal, combustion, and micro emulsion method [16,17,18,19]
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