Synthesis and Characterizationof Core-ShellFe3O4@Collagen Nanoparticle, and Application as Catalyst Ingreen Synthesis of Benzimidazoles and Benzithiazoles

Hossein Ghafuri,Majid Talebi,Elahe Esmaili

doi:10.3390/ecsoc-18-a032

Abstract

Nanoparticles are nanostructures with at least one dimensionbeing less than 100 nm.In this research, nano magnetic Fe3O4@collagen was prepared and characterized by Fourier transforms infrared spectroscopy (FT-IR) spectra, Scanning electron microscopy (SEM) images, energy dispersive X-ray spectroscopy (EDX) spectra, X-ray diffraction (XRD) measurements.Fe3O4@collagen is a new and greennano catalysis and using in synthesis of benzimidazoles and benzithiazoles.This method offers several advantages including high yields, short reaction times, easy work up procedure, reusability of catalyst and environmentally benign reaction conditions.

Highlights

The benzimidazoles and benzothiazoles have attracted much interest in diverse areas of chemistry
All reactions and the purity of benzimidazole and benzothiazole derivatives were monitored by thin-layer chromatography (TLC) using aluminum plates coated with silica gel F254 plates (Merck) using ethyl acetate, n-hexane and methanol as eluents
A mixture of aromatic aldehyde (1.0 mmol ), 1,2-phenylendiamine (1.0 mmol) were employed as reactants in the presence of catalytic amount of Fe3O4@Collagen (50 mg) and 4 mL of EtOH as solvent was stirred at room temperature for 10–60 min, the progress of the reaction was monitored by thin-layer chromatography (TLC). the catalyst washed with EtOH and after drying could be ready to use for the reaction without loss in activity

Summary

1.Introduction

The benzimidazoles and benzothiazoles have attracted much interest in diverse areas of chemistry These heterocycles have shown different pharmacological activities such as antibacterial, antiulcers, antihypertensives, antivirals, antifungals, anticancers, and antihistaminics. Benzimidazole derivatives exhibit significant activity against several viruses such as HIV, herpes (HSV-1), RNA, potential antitumor agents, antimicrobial agents and influenza. They act as topoisomerase inhibitors, selective neuropeptide YY1 receptor antagonists, angiotensinII inhibitors and smooth muscle cell proliferation inhibitors and have much more importance in organic synthesis [1]. In addition a number of methods have been reported for the synthesis of the benzothiazole by 2aminothiophenol with acyl chlorides or aldehydes which comprise the use of ionic liquid [7], refluxing in. Synthesis of benzimidazole derivatives catalysed by Fe3O4@Collagen at room temperature (25 °C) and synthesis of benzothiazole derivatives catalysed by Fe3O4@Collagen at reflux

Materials and methods

Results and discussions

12 Thiophen

4.Conclusion