Abstract
AbstractThe pharmaceutical and biologically active heterocyclic compounds including benzo[b][1,5]diazepines were efficiently synthesized via three-(in situ five-) component reactions of aromatic diamines, Meldrum’s acid, and isocyanide derivatives in the presence of zinc oxide nanoparticles at room temperature. ZnO nanoparticles, as an effective, mild, and reusable catalyst, significantly improved the reaction times and also the products were obtained in excellent yields. The prepared zinc oxide nanoparticles were fully characterized by EDX, XRD, BET, SEM, IR, and TEM analyses.
Highlights
Multi-component reactions (MCRs) have become a significantly important device for the fast preparation of various compound libraries
Pharmaceutical and biologically active heterocyclic compounds including benzodiazepine derivatives were efficiently synthesized in excellent yields and short reaction times using ZnO nanoparticles (ZnO NPs) at room temperature
The EDX spectrum of ZnO NPs shows the presence of zinc and oxygen as the only elementary components (Figure 2(A))
Summary
Multi-component reactions (MCRs) have become a significantly important device for the fast preparation of various compound libraries. The present protocol represents a simple and remarkable method for one-pot synthesis of some benzo[b][1,5]diazepines via three-(in situ five-) component reaction of aromatic diamines, Meldrum’s acid, and isocyanides in the presence of zinc oxide nanoparticles.
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