Abstract
The compound, C6H7N3OS, has been prepared and characterized by condensation between thiosemicarbazide and furan-2-carbaldehyde and its structure was elucidated by x-ray analysis (at 150 K), NMR and IR spectroscopy methods (at ambient temperature). It crystallizes in the monoclinic space groupP21/c(No. 14), a = 13.5099(3) Å, b = 5.67430(10) Å, c = 23.4755(6) Å, β= 117.367(2)°, V = 1598.20(7) Å3and Z = 8. The crystal structure was solved and refined to R = 0.0290 with 2942 unique reflections. No significant π-π interactions are found in the crystal structure. There are C-H…π interactions and also different weak hydrogen bonds, stabilizing the three dimensional crystal structure.
Highlights
Thiosemicarbazones and their derivatives have been widely studied due to their various biological activities such as anticancer activities[1,2]
It seems likely that the oxygen atom of the furan ring plays an important role in determining the biological activity[15]
Al reagents and solvents used in this study were purchased from Merck & Aldrich. (Z)-Furan-2-carbaldehyde thiosemicarbazone (I) was prepared according to the modified procedure described in the literature[1]
Summary
Thiosemicarbazones and their derivatives have been widely studied due to their various biological activities such as anticancer activities[1,2]. Transition metal complexes of thiosemicarbazone and their derivatives attracted considerable interest for their wide range of pharmacological properties such as antimicrobial[5,6], antiameobic[7], antitumor[8,9,10,11] and antiviral activity[12,13]. Many efforts were dedicated to investigate of the structure activity relationship of metal thiosemicarbazone complexes.
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