Abstract
In this study, L-lysine coated �a-Fe2O3 nanoparticles were synthesized by a chemical approach in two steps. In the first step �a-Fe2O3 nanoparticles were synthesized by a polyol-reduction method. XRD analysis confirmed the presence of cubic maghemite phase with an average crystallite size of 9.2 nm. SEM analysis showed that the prepared �a-Fe2O3 nanoparticles have a spherical structural morphology with the tendency of agglomeration and with size in the range 8.36- 10.69 nm. The �a-Fe2O3 nanoparticles were coated with L-lysine in the second stage in an aqueous dispersion with ultrasonication followed by a gentle heating at 40��C. FT-IR spectroscopy confirmed the presence of L-lysine on the nanoparticles surface and the Zeta potential also supported the coating of nanoparticles with a hydrophilic layer of amino acid (L-lysine) and a good stability in aqueous medium. Hysteresis loop shows a ferromagnetic behavior at room temperature for both samples.
Highlights
In the last years, sensitive magnetic nanoparticles have found multiples applications in different areas of bioscience, biotechnology, and environmental technologies
The most used biopolymers for coating of magnetic oxide particles reported in the literature are: polyethylene glycol (PEG) [23], polyvinyl alcohol (PVA) [24], dextran [25], chitosan [26], polyvinylpyrrolidone (PVP) [27]
Polyethylene glycol (PEG 200) (99%) purchased from Sigma-Aldrich was used as solvent, Sodium Acetate CH3COONa (99%) from REACTIVUL was used as a reducing agent, L-lysine as hydrophilic agent for coating from Sigma-Aldrich
Summary
Sensitive magnetic nanoparticles have found multiples applications in different areas of bioscience, biotechnology, and environmental technologies. The most used biopolymers for coating of magnetic oxide particles reported in the literature are: polyethylene glycol (PEG) [23], polyvinyl alcohol (PVA) [24], dextran [25], chitosan [26], polyvinylpyrrolidone (PVP) [27]. Another way to modify the surfaces of magnetic nanoparticles for biomedical applications is by bonding on their surface suitable chemicals that play an important role in the body. Amino acids are part of the desired chemical substances for modifying the surfaces of magnetic nanoparticles
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