Abstract
The Schotten-Baumann method is a well-known veritable tool for amide synthesis. Since quite a number of amide compounds have been shown to possess biological activities especially CNS activity a simple method for synthesizing new amides that are potential biologically active molecules was explored using the Schotten-Baumann method. The two compounds, N-prop-2-ynylacrylamide and N-prop-2-ynylbut-2-enamide were synthesized in good yields (42% and 56% respectively) by treating propargylamine with acryloyl chloride and crotonyl chloride respectively. The synthesized compounds were fully characterized by elemental analysis, NMR (1H and 13C), and mass spectral techniques. These demonstrated that the Schotten-Baumann method could be used to synthesized potentially useful carboxamides in good yields.Keywords: N-Prop-2-ynylacrylamide; N-Prop-2-ynylbut-2-enamide, Schotten Baumann method; Carboxamides
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