Abstract

AbstractA new method of preparing large spherical PVA beads (up to 1.5 mm diameter) with a core‐shell structure has been developed. This involves a stepwise saponification of suspension polymerized PVAc beads, followed by a stepwise crosslinking of the PVA core and shell with glutaraldehyde. The resulting composite PVA beads have thin, highly crosslinked outer shells and lightly to moderately crosslinked inner cores of different degrees of crosslinking. In addition to the characterization of structural parameters, the kinetics of solute release and the swelling dynamics, including the transient dimensional changes, have been investigated using proxyphylline as a model compound. © 1992 John Wiley & Sons, Inc.

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