Abstract
Many of mimic analogues synthesized before depending on the change in the structure of aromatic rings. In this work, the carbonyl group in the structure of compounds 1-4 converted to thiocarbonyl group, and then studying the toxicological activity due to chemical change in the active center of mimic analogues was performed for compounds N-tert-butyl-2,4-dichloro-N'-(2,4-dichlorobenzoyl)benzohydrazide (2) and N-tert-butyl-2,4-dichloro-N'-[(2,4-dichlorophenyl)carbonothioyl]benzenecarbothiohydrazide (6). The toxicological study was done by using 2nd and 4th instar larvae of the cotton leaf worm, Spodoptera littoralis (Boisd.). Five concentration levels (600, 300, 150, 75 and 37.5 ppm) of compounds (2) and (6) were applied on the fresh plant food to the newly grown (2nd and 4th) instar larvae.
Highlights
In Egypt among all cotton pests, the cotton leaf worm, Spodoptera littoralis (Boisd.), is the most important
It is extremely polyphagousand always appropriate to inflict excessive damage when it occurs in masses during certain years, commonly referred to as “cotton worm monsoons
Tebufenozide (Fig. 1) is registered for control of Lepidoptera insects, which mimic ecdysone and force insects to molt prematurely which typically results in stoppage of feeding and in insect death
Summary
In Egypt among all cotton pests, the cotton leaf worm, Spodoptera littoralis (Boisd.), is the most important. It is extremely polyphagousand always appropriate to inflict excessive damage when it occurs in masses during certain years, commonly referred to as “cotton worm monsoons.. Tebufenozide (Fig. 1) is registered for control of Lepidoptera insects, which mimic ecdysone and force insects to molt prematurely which typically results in stoppage of feeding and in insect death.. Tebufenozide is considered by many to be the safest, most selective, and most useful insect control agent ever to be discovered.. Analogues of tebufenozide such as methoxifenozide (RH-2485), halofenozide (RH-0345), and chromafenozide (ANS-118) have already been brought into agrochemical market.. Many of tebufenozide analogues synthesized due to their insecticidal activity. Tebufenozide is used to protect pomes fruit, canola, rice, almonds, sweet potato, cranberries, sugarcane, walnuts, pecan/pistachio nuts, cotton, turnips, mint, blueberries, forest/ornamental trees, pastures, rangelands, row crops, vegetables and vines. Tebufenozide is considered by many to be the safest, most selective, and most useful insect control agent ever to be discovered. At present, analogues of tebufenozide such as methoxifenozide (RH-2485), halofenozide (RH-0345), and chromafenozide (ANS-118) have already been brought into agrochemical market. Many of tebufenozide analogues synthesized due to their insecticidal activity.
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