Synthesis and characterization of some new heterocyclic compounds with two Heteroatom's (Nitrogen) in their cyclic

Abstract

The Pyrimidines derivatives play an essential role in several biological processes and have considerable important compounds for pharmaceutical medicinal and industrial material applications. The work describes the synthesis and characterization of some new pyrimidines derivatives: 2- mercapto 3,4 di hydro -4-oxo -[6- (4- alkoxy phenyl)- 4H)] pyrimidine -5- carbonitriles and 2- mercapto 3,4 di hydro -4-oxo -[6-(-4- substituted benzene - 4-H] pyrimidines -5- carbonitriles (3a-d). These Compounds (3a-d) were prepared from the reaction between ethylcyano acetate (0.01mole) and numbers of substituted benzaldehydes compounds (0.01mole) as starting materials. The compounds (4a-d) were obtained from the reaction of (3a-d) with aryl halide or alkyl halide under reflux for 5hrs, while the compounds (5a-d) were formed from the reaction of (4a-d) with phosophorous oxy chlorid. The compounds (6a-d) were synthesized from the reaction of (5a-d) with thiourea under reflux for 6hrs and the compounds (8a-d) were obtained from the reaction between (6a-d) with chloro acetic acid (0.01mole) under refluxed for 3hrs. All the synthesized compounds of pyrimidines derivatives were identified by the physical properties by it's melting points and colors, and the yields were characterized by the elemental (CHN) analysis, IR, UV, and visible spectra data.