Abstract
A new route for the synthesis of benzothiazolopyrazoline derivatives has been developed using various chalcone derivatives and 2-hydrazinobenzothiazole and piperidine catalyst. The product obtained in shorter reaction times and piperidine behaves as good catalyst for the cycloaddition rof chalcone and 2-hydrazinobenzothiazole. The reaction carried out in aqueous-ethanol medium at reflux condition and product obtained in high yield.
Highlights
Heterocycles containing nitrogen, sulphur and oxygen constitute the core structure of a number of biologically interesting compounds
The purity of the compounds was controlled by thin layer chromatography (TLC)
Hydrogen, nitrogen and sulphur were estimated by elemental analysis. 1H-NMR spectra were recorded on Waters spectrometer
Summary
Heterocycles containing nitrogen, sulphur and oxygen constitute the core structure of a number of biologically interesting compounds. Some nitrogen heterocyclic compounds were reported to be anticancer, antimicrobial and antiinflammatory agents. Because of interesting biological activity of various pyrazoline derivatives has been focused on this group. Benzothiazole and its derivatives have been known as a class of medicinal importance. Benzothiazole derivatives represent an extensive group of heterocyclic compounds, several of which have already found application in the medical sphere as medicines as well as in agriculture. Many of substituted benzothiazoles are known as substances with antibacterial and antifungal activities and are reported to be active as antineoplastics agent. Keeping in view the biological and clinical importance of benzothiazoles and pyrazolines, in this paper we report the synthesis and biological activity of new 3,5-diaryl-1-benzothiazolopyrazoline derivatives. Http://www.ijetmr.com©International Journal of Engineering Technologies and Management Research [94]
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