Abstract
Sodium alginate-g-2-hydroxyethyl methacrylate (HEMA) synthesis by free-radical polymerization using K2S2O8 as initiator has been carried out by varying 2-hydroxyethyl methacrylate concentration. Poly(HEMA)-grafted-sodium alginate beads were produced by a solvent evaporation technique using three different concentrations of glutaraldehyde as the cross-linking agent. The graft co-polymer beads were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy and X-ray diffraction. Scanning electron microscopy confirmed the spherical nature and surface morphology of particles with a mean particle size of 100 μm. The diffusional exponent (n) values of synthesized beads were found to be in the range 0.1973–0.4764, indicating a Fickian diffusion mechanism with chain relaxation controlled diffusion. Release data have been analyzed using an empirical equation to understand the nature of transport of drug containing solution through the polymeric matrices. The controlled release characteristic of the matrices for acebutolol hydrochloride was investigated in pH 7.4 media. Drug was released in a controlled manner up to 12 h.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
