Abstract
Since they were first developed in 2004, mesoporous bioactive glasses (MBGs) rapidly captured the interest of the scientific community thanks to their numerous beneficial properties. MBGs are synthesised by a combination of the sol–gel method with the chemistry of surfactants to obtain highly mesoporous (pore size from 5 to 20 nm) materials that, owing to their high surface area and ordered structure, are optimal candidates for controlled drug-delivery systems. In this work, we synthesised and characterised a silver-containing mesoporous bioactive glass (Ag-MBG). It was found that Ag-MBG is a suitable candidate for controlled drug delivery, showing a perfectly ordered mesoporous structure ideal for the loading of drugs together with optimal bioactivity, sustained release of silver from the matrix, and fast and strong bacterial inhibition against both Gram-positive and Gram-negative bacteria. Silver-doped mesoporous glass particles were used in three electrospinning-based techniques to produce PCL/Ag-MBG composite fibres, to coat bioactive glass scaffolds (via electrospraying), and for direct sol electrospinning. The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-MBG-based antibacterial controlled-delivery systems for tissue-engineering applications.
Highlights
Bioactive glasses (BGs) are noncrystalline materials that are able to bond with living tissue and stimulate new tissue growth [1,2]
The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-mesoporous bioactive glasses (MBGs)-based antibacterial controlled-delivery systems for tissue-engineering applications
The nonionic surfactant Pluronic® F127 was used as a structure directing agent and the evaporation-induced self-assembly (EISA) process was employed for the production of the mesoporous silver-doped glass (Ag-MBG)
Summary
Bioactive glasses (BGs) are noncrystalline materials that are able to bond with living tissue and stimulate new tissue growth [1,2]. Because of their high biomineralization ability, biodegradability, osteogenic, and angiogenic potential, BGs are promising candidates for tissue-engineering applications [2]. They have the capability to bond to both soft and hard tissues and to degrade once in contact with biological fluids. In 2004 a new family of sol–gel glasses was developed by
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