Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning.

Francesca E Ciraldo,Liliana Liverani,Aldo R Boccaccini,Wolfgang H Goldmann,Lukas Gritsch

doi:10.3390/ma11050692

Francesca E Ciraldo, Liliana Liverani + Show 3 more

Open Access

https://doi.org/10.3390/ma11050692

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Journal: Materials	Publication Date: Apr 28, 2018
Citations: 46	License type: CC BY 4.0

Affiliation: University of Erlangen-Nuremberg

Abstract

Since they were first developed in 2004, mesoporous bioactive glasses (MBGs) rapidly captured the interest of the scientific community thanks to their numerous beneficial properties. MBGs are synthesised by a combination of the sol–gel method with the chemistry of surfactants to obtain highly mesoporous (pore size from 5 to 20 nm) materials that, owing to their high surface area and ordered structure, are optimal candidates for controlled drug-delivery systems. In this work, we synthesised and characterised a silver-containing mesoporous bioactive glass (Ag-MBG). It was found that Ag-MBG is a suitable candidate for controlled drug delivery, showing a perfectly ordered mesoporous structure ideal for the loading of drugs together with optimal bioactivity, sustained release of silver from the matrix, and fast and strong bacterial inhibition against both Gram-positive and Gram-negative bacteria. Silver-doped mesoporous glass particles were used in three electrospinning-based techniques to produce PCL/Ag-MBG composite fibres, to coat bioactive glass scaffolds (via electrospraying), and for direct sol electrospinning. The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-MBG-based antibacterial controlled-delivery systems for tissue-engineering applications.

Highlights

Bioactive glasses (BGs) are noncrystalline materials that are able to bond with living tissue and stimulate new tissue growth [1,2]
The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-mesoporous bioactive glasses (MBGs)-based antibacterial controlled-delivery systems for tissue-engineering applications
The nonionic surfactant Pluronic® F127 was used as a structure directing agent and the evaporation-induced self-assembly (EISA) process was employed for the production of the mesoporous silver-doped glass (Ag-MBG)

Summary

Introduction

Bioactive glasses (BGs) are noncrystalline materials that are able to bond with living tissue and stimulate new tissue growth [1,2]. Because of their high biomineralization ability, biodegradability, osteogenic, and angiogenic potential, BGs are promising candidates for tissue-engineering applications [2]. They have the capability to bond to both soft and hard tissues and to degrade once in contact with biological fluids. In 2004 a new family of sol–gel glasses was developed by

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