Synthesis and Characterization of Silicone Contact Lenses Based on TRIS-DMA-NVP-HEMA Hydrogels.

Nguyen-Phuong-Dung Tran,Ming-Chien Yang

doi:10.3390/polym11060944

Nguyen-Phuong-Dung Tran, Ming-Chien Yang

Open Access

https://doi.org/10.3390/polym11060944

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Journal: Polymers	Publication Date: May 31, 2019
Citations: 59	License type: CC BY 4.0

Affiliation: National Taiwan University of Science and Technology

Abstract

In this study, silicone-based hydrogel contact lenses were prepared by the polymerization of 3-(methacryloyloxy)propyltris(trimethylsiloxy)silane (TRIS), N,N-dimethylacrylamide (DMA), 1-vinyl-2-pyrrolidinone (NVP), and 2-hydroxyethylmethacrylate (HEMA). The properties of silicone hydrogel lenses were analyzed based on the methods such as equilibrium water content, oxygen permeability, optical transparency, contact angle, mechanical test, protein adsorption, and cell toxicity. The results showed that the TRIS content in all formulations increased the oxygen permeability and decreased the equilibrium water content, while both DMA and NVP contributed the hydrophilicity of the hydrogels. The maximum value of oxygen permeability was 74.9 barrers, corresponding to an equilibrium water content of 44.5% as well as a contact angle of 82°. Moreover, L929 fibroblasts grew on all these hydrogels, suggesting non-cytotoxicity. In general, the silicone hydrogels in this work exhibited good oxygen permeability, stiffness, and optical transparency as well as anti-protein adsorption. Hence, these silicone hydrogel polymers would be feasible for making contact lens.

Highlights

Hydrogel is frequently used in fields including biology, medicine, material science and engineering.In particular, hydrogel has been applied in contact lenses due to impressive function such as wettability, biocompatibility, optical characteristic, and mechanical strength [1]
The results demonstrate that water content of the lens material depended on the content of hydrophobic TRIS
In the TDNH series, with the incorporation of HEMA, equilibrium water content (EWC) was influenced by the TRIS content

Summary

Introduction

Hydrogel is frequently used in fields including biology, medicine, material science and engineering.In particular, hydrogel has been applied in contact lenses due to impressive function such as wettability, biocompatibility, optical characteristic, and mechanical strength [1]. Hydrogel is frequently used in fields including biology, medicine, material science and engineering. Hydrogel lens limits gas permeability, especially oxygen permeability. High oxygen permeability is very significant to maintaining the wearing comfort and to restrict hypoxia-related complications, such as dry eyes and corneal edema [2,3], as hypoxia frequently occurs in patients who wear contact lenses for long durations. To reduce the shortage of oxygen supply, the hydrophobic materials containing siloxane groups such as hydroxyl-terminated polydimethylsiloxane (PDMS) and tris-(trimethyl-silyl-propyl-methacrylate) (TRIS). The cooperation of 2-methacryloyloxyethyl phosphorylcholine and vinyl ether terminated polydimethylsiloxane macro-monomer, improved the oxygen permeability of hydrogel contact lenses [4]. The polymerization of 2-hydroxyethyl methacrylate (HEMA) with PDMS provided more oxygen permeability than non-silicone hydrogel [5]

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Results

Conclusion