Abstract
A Schiff base, 3-Hydroxy-4-(3-hydroxy benzylidene amino) benzoic acid was synthesized from the corresponding startingketone, 3-Hydroxy benzaldehyde and amine, 3-hydroxy 4-amino benzoic acid by condensation reaction. Further, themetal complexes of the Schiff base with Ni(II) and Zn(II) were synthesized. These Schiff base and its Ni(II) and Zn(II)metal complexes were characterized by spectral techniques like FT-IR, 1H NMR and 13C NMR spectroscopy. Thesynthesized compounds were evaluated for their antibacterial activity against Gram positive and negative bacteria likeStaphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The anti-fungal activities were also studiedfor Candida albicans, Candida parapsilosis. The Zn(II) metal complex exhibited the good antibacterial and antifungal activityamong the all prepared compounds.
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