Abstract
This work describes the synthesis of SBA-16 modified with amine groups and chitosan. The synthesized materials were characterized by small angle XRD (SXRD), wide angle XRD (WXRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier-transformed Infra-red (FTIR) spectroscopy and nitrogen adsorption/desorption techniques. The characterization results revealed that the new materials show highly ordered mesostructure with large surface area and pore diameter, suitable for further applications. FTIR, WXRD, TGA data and elemental analyses proved that amine groups/chitosan were uniformly dispersed on SBA-16 surface. The materials obtained can be considered as safe, on the basis of insignificant cytotoxic effect against a human colon cancer cell line Caco-2. The preliminary tests have shown that the SBA-16 materials are able to modify the release profile of furosemide (FUR), a poorly soluble active substance of Class IV of the Biopharmaceutics Classification System (BCS).
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