Abstract
Series of compounds 2,4-bis-phenylamino-6-[4'-{2-(substituted phenyl/cinnamyl/2'-furanyl/2'-thienyl)-2,3-dihydro-1,5-benzothiazepine-4-yl}phenyl aininol-s-triazine 7(a-f) were prepared by reaction of different chalcones and 2-amino thiophenol in the presence of glacial acetic acid. Chalcones 6(a-f) on cyclisation with hydroxylamine hydrochloride in the presence of alkali gave 2,4-bis-phenylamino-6-[4'-{5-(substituted phenyl/cinnamyl/2'-furanyl/2'-thienyl)-2-isoxazol-3-yl}phenyl amino/-s-triazine 8(a-f). The products were characterized by elemental analysis, IR and 1 H NMR data. All the synthesized compounds have been evaluated for their in vitro antibacterial activity against four different strain viz. S. aureus (MTCC-96), B. subtilis (MTCC-441) (Gram-positive bacteria) and E. coli (MTCC-443), S. paratyphi-B (MTCC-733) (Gram-negative bacteria) by agar diffusion method.
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