Abstract
Biodegradable polyrotaxane-based triblock copolymers were synthesized via the bulk atom transfer radical polymerization (ATRP) of n-butyl methacrylate (BMA) initiated with polypseudo-rotaxanes (PPRs) built from a distal 2-bromoisobutyryl end-capped poly(e-caprolactone) (Br-PCL-Br) with α-cyclodextrins (α-CDs) in the presence of Cu(I)Br/N,N,N′,N″,N″-pentamethyldiethylenetriamine at 45 oC. The structure was characterized in detail by means of 1H NMR, gel permeation chromatography, wide-angle X-ray diffraction, DSC and TGA. When the feed molar ratio of BMA to Br-PCL-Br was changed from 128 to 300, the degree of polymerization of PBMA blocks attached to two ends of the PPRs was in the range 382 − 803. Although about a tenth of the added α-CDs were still threaded onto the PCL chain after the ATRP process, the movable α-CDs made a marked contribution to the mechanical strength enhancement, blood anticoagulation activity and protein adsorption repellency of the resulting copolymers. Meanwhile, they could also protect the copolymers from the attack of H2O and Lipase AK Amano molecules, exhibiting a lower mass loss as evidenced in hydrolytic and enzymatic degradation experiments. © 2013 Society of Chemical Industry
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
